The Loneliest Number

Eon.

As in:

e·on
ˈēən,ˈēˌän/
noun
  1. 1.
    an indefinite and very long period of time, often a period exaggerated for humorous or rhetorical effect.
    “he reached the crag eons before I arrived”

Alternatively, NOE could be the loneliest number. That’s the nuclear overhauser effect.

Meet NOE’s friends:

Other experimental techniques exploiting the NOE include and are not limited to:

HOESY, Heteronuclear Overhauser Effect Spectroscopy
ROESY, Rotational Frame Nuclear Overhauser Effect Spectroscopy
TRNOE, Transferred Nuclear Overhauser Effect
DPFGSE-NOE, Double Pulsed Field Gradient Spin Echo NOE experiment

In any case, this post was constructed to prove that 1 is not a lonely number.

Now, the question remains: what is the loneliest letter?

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